Elevated Soluble Triggering Receptor Expressed on Myeloid Cells (sTREM)-1 Levels in Maternal Serum during Term and Preterm Labor

Tency, Inge; Verstraelen, Hans; Saerens, Bart; Verhasselt, Bruno; Vaneechoutte, Mario; Degomme, Olivier; Verhelst, Rita; Temmerman, Marleen

doi:10.1371/journal.pone.0056050

Elevated Soluble Triggering Receptor Expressed on Myeloid Cells (sTREM)-1 Levels in Maternal Serum during Term and Preterm Labor

Author:

Tency, Inge

Verstraelen, Hans ; Saerens, Bart ; Verhasselt, Bruno ; Vaneechoutte, Mario ; Degomme, Olivier ; Verhelst, Rita ; Temmerman, Marleen

Keywords:

Adult, Female, Hospitalization, Humans, Labor, Obstetric, Membrane Glycoproteins, Obstetric Labor, Premature, Pregnancy, Receptors, Immunologic, Time Factors, Young Adult, Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, INTRAUTERINE INFECTION, INFLAMMATORY MARKERS, AMNIOTIC-FLUID, TREM-1, MEMBRANES, RISK, INTERLEUKIN-6, PARTURITION, PREGNANCY, DIAGNOSIS, Triggering Receptor Expressed on Myeloid Cells-1, General Science & Technology

Abstract:

Infection and inflammation are important mechanisms leading to preterm birth. Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) belongs to a family of cell surface receptors that seems to play an important role in fine-tuning the immune response. It has been demonstrated that sTREM-1 is involved in bacterial infection as well as in non-infectious inflammatory conditions. Few studies have investigated serum sTREM-1 expression during preterm labor. Therefore, the purpose of this study was to assess sTREM-1 concentrations in maternal serum during term and preterm labor.