Title: BMP signaling in vascular biology and dysfunction
Authors: Garci­a de Vinuesa, Amaya
Abdelilah-Seyfried, Salim
Knaus, Petra
Zwijsen, An #
Bailly, Sabine # ×
Issue Date: 5-Dec-2015
Publisher: Elsevier Science
Series Title: Cytokine & Growth Factor Reviews
Abstract: The vascular system is critical for developmental growth, tissue homeostasis and repair but also for tumor development. Bone morphogenetic protein (BMP) signaling has recently emerged as a fundamental pathway of the endothelium by regulating cardiovascular and lymphatic development and by being causative for several vascular dysfunctions. Two vascular disorders have been directly linked to impaired BMP signaling, pulmonary arterial hypertension and hereditary hemorrhagic telangiectasia. Endothelial BMP signaling critically depends on the cellular context, which includes among others vascular heterogeneity, exposure to flow, and the intertwining with other signaling cascades (Notch, WNT, Hippo and hypoxia). The purpose of this review is to highlight the most recent findings illustrating the clear need for reconsidering the role of BMPs in vascular biology.
ISSN: 1359-6101
Publication status: accepted
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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