Title: Effect of GTS-21, An Alpha7 Nicotinic Acetylcholine Receptor Agonist, on Clp-Induced Inflammatory, Gastrointestinal Motility and Colonic Permeability Changes in Mice
Authors: Nullens, Sara
Staessens, Michael
Peleman, Cédric
Schrijvers, Dorien M
Malhotra-Kumar, Surbhi
Francque, Sven
Matteoli, Gianluca
Boeckxstaens, Guy
De Man, Joris G
De Winter, Benedicte Y # ×
Issue Date: Apr-2016
Publisher: BioMedical Press
Series Title: Shock vol:45 issue:4 pages:450-9
Abstract: During abdominal sepsis, the inhibition of gastrointestinal (GI) motility together with mucosal barrier dysfunction will lead to increased bacterial translocation and maintenance of sepsis. The activation of the vagal anti-inflammatory pathway remains an appealing therapeutic strategy in sepsis. In this respect, selective alpha7 nicotinic acetylcholine receptor (α7nAChR) agonists have shown anti-inflammatory properties in several animal models of inflammation.
ISSN: 1073-2322
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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