Title: Erbulozole (pinn) (r-55-104) encapsulated into cyclodextrins - has it a combined antitumoral and radioprotective potential
Authors: Distelmans, W
Vanginckel, R
Vanherck, W
Willebrords, R
Wouters, Leo
Debrabander, M
Mesens, J
Issue Date: Jan-1991
Publisher: Int inst anticancer research
Series Title: Anticancer research vol:11 issue:1 pages:253-256
Abstract: The clinically applicable formulation of the microtubule inhibitor erbulozole (R 55 104), dissolved into an aqueous hydroxypropyl-beta-cyclodextrin solution (designated as R 55 104-CYCLO), exerts a similiar effect on growth delay of subcutanous MO4 fibrosarcomas in mice, with or without 10 Gy gamma-irradiation given locally to the tumors 2 h later, compared to R 55 104 in water. The drug concentration can be reduced from 80 mg/kg to 5 mg/kg without affecting the activity of this particular drug-radiation combination. Furthermore, 80 mg/kg R 55 104-CYCLO show a radioprotective effect when given 2 h before total body irradiation of non-tumor bearing mice. A radiation dose of 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 Gy respectively was given resulting in a LD50(30) of 5.97 Gy for the irradiated mice and 7.65 Gy for the drug-radiation treated animals (Dose Effect Factor = 0.78). Therapeutic implications of both observations are discussed.
ISSN: 0250-7005
Publication status: published
KU Leuven publication type: DI
Appears in Collections:Department of Rehabilitation Sciences - miscellaneous

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science