Title: High-content analysis of α-synuclein aggregation and cell death in a cellular model of Parkinson's disease
Authors: Macchi, Francesca ×
Deleersnijder, Angélique
Van Den Haute, Chris
Munck, Sebastian
Pottel, Hans
Michiels, Annelies
Debyser, Zeger
Gerard, Melanie
Baekelandt, Veerle #
Issue Date: Nov-2015
Publisher: Elsevier/North-Holland
Series Title: Journal of Neuroscience Methods vol:261 pages:117-127
Article number: S0165-0270(15)00411-2
Abstract: Alpha-synuclein (α-SYN) aggregates represent a key feature of Parkinson's disease, but the exact relationship between α-SYN aggregation and neurodegeneration remains incompletely understood. Therefore, the availability of a cellular assay that allows medium-throughput analysis of α-SYN-linked pathology will be of great value for studying the aggregation process and for advancing α-SYN-based therapies.
ISSN: 0165-0270
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Public Health and Primary Care, Campus Kulak Kortrijk
Research Group for Neurobiology and Gene Therapy
Department of Human Genetics - miscellaneous
Molecular Virology and Gene Therapy
× corresponding author
# (joint) last author

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