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Title: Role of the Gut Microbiome in Uremia: A Potential Therapeutic Target
Authors: Ramezani, Ali ×
Massy, Ziad A
Meijers, Björn
Evenepoel, Pieter
Vanholder, Raymond
Raj, Dominic S #
Issue Date: Mar-2016
Publisher: W.B. Saunders
Series Title: American Journal of Kidney Diseases vol:67 issue:3 pages:483-98
Article number: S0272-6386(15)01311-6
Abstract: Also known as the "second human genome," the gut microbiome plays important roles in both the maintenance of health and the pathogenesis of disease. The symbiotic relationship between host and microbiome is disturbed due to the proliferation of dysbiotic bacteria in patients with chronic kidney disease (CKD). Fermentation of protein and amino acids by gut bacteria generates excess amounts of potentially toxic compounds such as ammonia, amines, thiols, phenols, and indoles, but the generation of short-chain fatty acids is reduced. Impaired intestinal barrier function in patients with CKD permits translocation of gut-derived uremic toxins into the systemic circulation, contributing to the progression of CKD, cardiovascular disease, insulin resistance, and protein-energy wasting. The field of microbiome research is still nascent, but is evolving rapidly. Establishing symbiosis to treat uremic syndrome is a novel concept, but if proved effective, it will have a significant impact on the management of patients with CKD.
URI: 
ISSN: 0272-6386
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Nephrology
× corresponding author
# (joint) last author

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