Title: Stem Cell-Derived Oligodendroglial Cells for Therapy in Neurological Diseases
Authors: Garcia Leon, Juan Antonio ×
Verfaillie, Catherine #
Issue Date: 2016
Publisher: Bentham Science Publishers Ltd.
Series Title: Current Stem Cell Research & Therapy vol:11 issue:7
Article number: 26329482
Abstract: There are an important number of neurological diseases where not neurons but glia are the responsible cells for the degeneration of the nervous system. In the last years, determinant roles for oligodendrocytes (OLs) have been demonstrated not only in myelin generation and maintenance but also for metabolic support of neurons. Oligodendroglial defects lead to brain degeneration in several diseases, supporting the idea that not only endogenous regeneration but also administration of exogenous OL precursors will lead to overcome functional deficits. In this review, we discuss the many diseases where OLs play a crucial role, and focus on the different sources and methods to obtain oligodendroglial cells that could be used in cell therapy for myelin-related and oligodendrocyte-deficient diseases.
ISSN: 1574-888X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Stem Cell Biology and Embryology (+)
× corresponding author
# (joint) last author

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