RANK/OPG ratio of expression in primary clear-cell renal cell carcinoma is associated with bone metastasis and prognosis in patients treated with anti-VEGFR-TKIs

Beuselinck, Benoit; Jean-Baptiste, J; Couchy, G; Job, S; De Reynies, A; Wolter, Pascal; Théodore, C; Gravis, G; Rousseau, B; Albiges, L; Joniau, Steven; Verkarre, V; Lerut, Evelyne; Patard, JJ; Schöffski, Patrick; Méjean, A; Elaidi, R; Oudard, S; Zucman-Rossi, J

doi:10.1038/bjc.2015.352

RANK/OPG ratio of expression in primary clear-cell renal cell carcinoma is associated with bone metastasis and prognosis in patients treated with anti-VEGFR-TKIs

Author:

Beuselinck, Benoit

Jean-Baptiste, J ; Couchy, G ; Job, S ; De Reynies, A ; Wolter, Pascal ; Théodore, C ; Gravis, G ; Rousseau, B ; Albiges, L ; Joniau, Steven ; Verkarre, V ; Lerut, Evelyne ; Patard, JJ ; Schöffski, Patrick ; Méjean, A ; Elaidi, R ; Oudard, S ; Zucman-Rossi, J

Keywords:

Science & Technology, Life Sciences & Biomedicine, Oncology, Renal cell carcinoma, bone metastases, outcome, RANK/RANKL/OPG pathway, anti-VEGFR-TKIs, prognosis, Bone Neoplasms, Carcinoma, Renal Cell, Disease-Free Survival, Female, Genes, src, Humans, Intercellular Signaling Peptides and Proteins, Kidney Neoplasms, Male, Middle Aged, Osteoprotegerin, Prognosis, Protein Kinase Inhibitors, Protein-Tyrosine Kinases, Proto-Oncogene Mas, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B, Receptors, Vascular Endothelial Growth Factor, Signal Transduction, 1112 Oncology and Carcinogenesis, 1117 Public Health and Health Services, Oncology & Carcinogenesis, 3211 Oncology and carcinogenesis

Abstract:

Bone metastases (BMs) are associated with poor outcome in metastatic clear-cell renal carcinoma (m-ccRCC) treated with anti-vascular endothelial growth factor tyrosine kinase inhibitors (anti-VEGFR-TKIs). We aimed to investigate whether expression in the primary tumour of genes involved in the development of BM is associated with outcome in m-ccRCC patients treated with anti-VEGFR-TKIs.