Sirolimus use in liver transplant recipients with hepatocellular carcinoma: A randomized, multicenter, open-label phase 3 trial

Geissler, Edward K; Schnitzbauer, Andreas A; Zülke, Carl; Lamby, Philipp E; Proneth, Andrea; Duvoux, Christophe; Burra, Patrizia; Jauch, Karl-Walter; Rentsch, Markus; Ganten, Tom M; Settmacher, Utz; Heise, Michael; Rossi, Giorgio; Cillo, Umberto; Kneteman, Norman; Adam, René; van Hoek, Bart; Bachellier, Philippe; Wolf, Philippe; Rostaing, Lionel; Bechstein, Wolf O; Rizell, Magnus; Powell, James; Hidalgo, Ernest; Gugenheim, Jean; Wolters, Heiner; Brockmann, Jens; Roy, André; Mutzbauer, Ingrid; Schlitt, Angela; Beckebaum, Susanne; Graeb, Christian; Nadalin, Silvio; Valente, Umberto; Turrión, Victor Sánchez; Jamieson, Neville; Scholz, Tim; Colledan, Michele; Fändrich, Fred; Becker, Thomas; Söderdahl, Gunnar; Chazouillères, Olivier; Mäkisalo, Heikki; Pageaux, Georges-Philippe; Steininger, Rudolf; Soliman, Thomas; de Jong, Koert P; Pirenne, Jacques; Margreiter, Raimund; Pratschke, Johann; Pinna, Antonio D; Hauss, Johann; Schreiber, Stefan; Strasser, Simone; Klempnauer, Jürgen; Troisi, Roberto I; Bhoori, Sherrie; Lerut, Jan; Bilbao, Itxarone; Klein, Christian G; Königsrainer, Alfred; Mirza, Darius F; Otto, Gerd; Mazzaferro, Vincenzo; Neuhaus, Peter; Schlitt, Hans J; Schmidt, Jan

doi:10.1097/TP.0000000000000965

Sirolimus use in liver transplant recipients with hepatocellular carcinoma: A randomized, multicenter, open-label phase 3 trial

Author:

Geissler, Edward K

Schnitzbauer, Andreas A ; Zülke, Carl ; Lamby, Philipp E ; Proneth, Andrea ; Duvoux, Christophe ; Burra, Patrizia ; Jauch, Karl-Walter ; Rentsch, Markus ; Ganten, Tom M ; Settmacher, Utz ; Heise, Michael ; Rossi, Giorgio ; Cillo, Umberto ; Kneteman, Norman ; Adam, René ; van Hoek, Bart ; Bachellier, Philippe ; Wolf, Philippe ; Rostaing, Lionel ; Bechstein, Wolf O ; Rizell, Magnus ; Powell, James ; Hidalgo, Ernest ; Gugenheim, Jean ; Wolters, Heiner ; Brockmann, Jens ; Roy, André ; Mutzbauer, Ingrid ; Schlitt, Angela ; Beckebaum, Susanne ; Graeb, Christian ; Nadalin, Silvio ; Valente, Umberto ; Turrión, Victor Sánchez ; Jamieson, Neville ; Scholz, Tim ; Colledan, Michele ; Fändrich, Fred ; Becker, Thomas ; Söderdahl, Gunnar ; Chazouillères, Olivier ; Mäkisalo, Heikki ; Pageaux, Georges-Philippe ; Steininger, Rudolf ; Soliman, Thomas ; de Jong, Koert P ; Pirenne, Jacques ; Margreiter, Raimund ; Pratschke, Johann ; Pinna, Antonio D ; Hauss, Johann ; Schreiber, Stefan ; Strasser, Simone ; Klempnauer, Jürgen ; Troisi, Roberto I ; Bhoori, Sherrie ; Lerut, Jan ; Bilbao, Itxarone ; Klein, Christian G ; Königsrainer, Alfred ; Mirza, Darius F ; Otto, Gerd ; Mazzaferro, Vincenzo ; Neuhaus, Peter ; Schlitt, Hans J ; Schmidt, Jan

Keywords:

Science & Technology, Life Sciences & Biomedicine, Immunology, Surgery, Transplantation, RENAL-CELL CARCINOMA, RAPAMYCIN INHIBITORS, IMMUNOSUPPRESSION, RECURRENCE, SURVIVAL, TARGET, CANCER, METAANALYSIS, PROGRESSION, EVEROLIMUS, Adult, Age Factors, Aged, Australia, Canada, Carcinoma, Hepatocellular, Disease Progression, Disease-Free Survival, Drug Therapy, Combination, Europe, Female, Humans, Immunosuppressive Agents, Intention to Treat Analysis, Kaplan-Meier Estimate, Liver Neoplasms, Liver Transplantation, Male, Middle Aged, Neoplasm Recurrence, Local, Prospective Studies, Risk Assessment, Risk Factors, Sirolimus, TOR Serine-Threonine Kinases, Time Factors, Treatment Outcome, Young Adult, 11 Medical and Health Sciences, 3202 Clinical sciences, 3204 Immunology

Abstract:

We investigated whether sirolimus-based immunosuppression improves outcomes in liver transplantation (LTx) candidates with hepatocellular carcinoma (HCC).