Title: The contribution of dorsomedial and dorsolateral striatum during different phases of Morris water maze training
Authors: Pooters, Tine
Gantois, Ilse
Vermaercke, Ben
D'Hooge, Rudi
Issue Date: Oct-2015
Conference: Annual Meeting of The Society for Neuroscience. edition:45 location:Chicago, IL, USA date:17-21 October 2016
Abstract: Impairments in cognitive and executive functioning occur in different basal ganglia disorders (e.g. schizophrenia and Parkinson’s disease), and remain largely intractable with available treatments. The striatum, the largest area of the basal ganglia, has been suggested to contribute significantly to these cognitive deficits, but the specific role and time-dependent involvement of striatal subregions in cognitive (dys)functioning remain unclear. Therefore, we studied spatial learning and memory in mice with lesions in dorsomedial (DMS) and dorsolateral striatum (DLS). Animals were trained for 15 days in the hidden-platform version of the Morris water maze. To determine the time-dependent involvement of DMS and DLS, lesions were applied during different phases of MWM training (before training or after 5 or 10 days of acquisition training). Compared to sham controls, animals that received DMS damage before training were severely impaired during acquisition training, whereas animals with DLS lesions did not show any impairment at all. DMS-damaged mice displayed delayed acquisition, increased thigmotaxis and increased distance to the platform during the entire course of training, but when lesions were applied after 5 or 10 days of training, performance was similar to controls. Search strategy analysis indicated that the deficits due to DMS damage coincided with decreased ability to switch flexibly between spatial, non-spatial and repetitive search strategies. In conclusion, these data suggest that DMS (but not DLS) is crucial during the initial phase of acquisition, and that DMS controls goal-directed behaviours.
Publication status: accepted
KU Leuven publication type: IMa
Appears in Collections:Laboratory for Biological Psychology

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