Importance of amygdala noradrenergic activity and large-scale neural networks in regulating emotional arousal effects on perception and memory
Roozendaal, Benno * × Luyten, Laura * de Voogd, Lycia D. Hermans, Erno J. #
Cambridge University Press
Behavioral and Brain Sciences
Mather and colleagues postulate that norepinephrine promotes selective processing of emotionally salient information through local “hotspots” where norepinephrine release interacts with glutamatergic activity. However, rodent and human findings show that norepinephrine is
ineffective in modulating mnemonic processes in absence of a functional amygdala. We therefore argue that emphasis should shift towards modulatory effects of amygdala-driven changes at the network level.