Title: Cross-biome comparison of microbial association networks
Authors: Faust, Karoline ×
Lima Mendez, Gipsi
Lerat, Jean-Sébastien
Sathirapongsasuti, Jarupon Fah
Knight, Rob
Huttenhower, Curtis
Lenaerts, Tom
Raes, Jeroen #
Issue Date: Oct-2015
Publisher: Frontiers Research Foundation
Series Title: Frontiers in Microbiology vol:6
Article number: 01200
Abstract: Clinical and environmental meta-omics studies are accumulating an ever-growing amount of microbial abundance data over a wide range of ecosystems. With a sufficiently large sample number, these microbial communities can be explored by constructing and analyzing co-occurrence networks, which detect taxon associations from abundance data and can give insights into community structure. Here, we investigate how co-occurrence networks differ across biomes and which other factors influence their properties. For this, we inferred microbial association networks from 20 different 16S rDNA sequencing data sets and observed that soil microbial networks harbor proportionally fewer positive associations and are less densely interconnected than host-associated networks. After excluding sample number, sequencing depth and beta-diversity as possible drivers, we found a negative correlation between community evenness and positive edge percentage. This correlation likely results from a skewed distribution of negative interactions, which take place preferentially between less prevalent taxa. Overall, our results suggest an under-appreciated role of evenness in shaping microbial association networks.
ISSN: 1664-302X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Molecular Bacteriology (Rega Institute)
× corresponding author
# (joint) last author

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