Title: Tryptophan dendrimers that inhibit HIV replication, prevent virus entry and bind to the HIV envelope glycoproteins gp120 and gp41
Authors: Rivero-Buceta, Eva ×
Doyagüez, Elisa G
Colomer, Ignacio
Quesada, Ernesto
Mathys, Leen
Noppen, Sam
Liekens, Sandra
Camarasa, María-José
Pérez-Pérez, María-Jesús
Balzarini, Jan
San-Félix, Ana #
Issue Date: Dec-2015
Series Title: European Journal of Medicinal Chemistry vol:106 pages:34-43
Article number: S0223-5234(15)30313-5
Abstract: Dendrimers containing from 9 to 18 tryptophan residues at the peryphery have been efficiently synthesized and tested against HIV replication. These compounds inhibit an early step of the replicative cycle of HIV, presumably virus entry into its target cell. Our data suggest that HIV inhibition can be achieved by the preferred interaction of the compounds herein described with glycoproteins gp120 and gp41 of the HIV envelope preventing interaction between HIV and the (co)receptors present on the host cells. The results obtained so far indicate that 9 tryptophan residues on the periphery are sufficient for efficient gp120/gp41 binding and anti-HIV activity.
ISSN: 0223-5234
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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