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Annual Meeting of the Society-of-Nuclear-Medicine-and-Molecular-Imaging (SNMMI), Date: 2014/06/07 - 2014/06/11, Location: MO, St Louis

Publication date: 2014-05-01
Volume: 55
Publisher: Society of Nuclear Medicine

Journal Of Nuclear Medicine

Author:

Postnov, Andrey
Gheysens, Olivier ; de Hoon, Jan ; Declercq, Ruben ; Dennie, Justin ; Mixson, Lori ; De Lepeleire, Inge ; Van Laere, Koenraad ; Klimas, Michael ; Chakravarthy, Manu

Keywords:

Science & Technology, Life Sciences & Biomedicine, Radiology, Nuclear Medicine & Medical Imaging, 1103 Clinical Sciences, Nuclear Medicine & Medical Imaging, 3202 Clinical sciences

Abstract:

The quantification and variability of skeletal muscle glucose utilization (SMGU) in healthy subjects under basal (low insulin) conditions are poorly known. This information is essential early in clinical drug development to effectively interrogate novel pharmacologic interventions that modulate glucose uptake. The aim of this study was to determine test-retest characteristics and variability of SMGU within and between healthy subjects under basal conditions. Furthermore, different kinetic modeling strategies were evaluated to find the best-fitting model to assess SMGU studied by (18)F-FDG.