Title: NMR-based conformational analysis of 2',6-disubstituted uridines and antiviral evaluation of new phosphoramidate prodrugs
Authors: da Paixão Soares, Fábio ×
Groaz, Elisabetta
Lescrinier, Eveline
Neyts, Johan
Leyssen, Pieter
Herdewijn, Piet #
Issue Date: Sep-2015
Publisher: Pergamon
Series Title: Bioorganic & Medicinal Chemistry vol:23 pages:5809-5815
Article number: S0968-0896(15)00570-2
Abstract: Six novel phosphoramidate prodrugs of uridine analogues, with structural modifications introduced at the 6- and 2',6-positions, have been prepared and evaluated for selective antiviral activity against hepatitis C virus, as well as other positive-stranded RNA viruses. An analysis of the conformational properties of the parent nucleosides was carried out using two-dimensional NMR spectroscopy based experiments, highlighting a 3'-endo (North) sugar puckering preference and syn orientation.
ISSN: 0968-0896
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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