CRF19_cpx is an evolutionary fit HIV-1 variant strongly associated with rapid progression to AIDS in Cuba

Kouri, Vivian; Khouri, Ricardo; Alemán, Yoan; Abrahantes, Yeissel; Vercauteren, Jurgen; Pineda-Peña, Andrea-Clemencia; Theys, Kristof; Megens, Sarah; Moutschen, Michel; Pfeifer, Nico; Van Weyenbergh, Johan; Pérez, Ana B; Pérez, Jorge; Pérez, Lissette; Van Laethem, Kristel; Vandamme, Anne-Mieke

doi:10.1016/j.ebiom.2015.01.015

CRF19_cpx is an evolutionary fit HIV-1 variant strongly associated with rapid progression to AIDS in Cuba

Author:

Kouri, Vivian

Khouri, Ricardo ; Alemán, Yoan ; Abrahantes, Yeissel ; Vercauteren, Jurgen ; Pineda-Peña, Andrea-Clemencia ; Theys, Kristof ; Megens, Sarah ; Moutschen, Michel ; Pfeifer, Nico ; Van Weyenbergh, Johan ; Pérez, Ana B ; Pérez, Jorge ; Pérez, Lissette ; Van Laethem, Kristel ; Vandamme, Anne-Mieke

Keywords:

Science & Technology, Life Sciences & Biomedicine, Medicine, General & Internal, Medicine, Research & Experimental, General & Internal Medicine, Research & Experimental Medicine, CRF19, HIV-1, Variant, Progression to AIDS, Cuba, HUMAN-IMMUNODEFICIENCY-VIRUS, DISEASE PROGRESSION, DRUG-RESISTANCE, SUBTYPE-A, MOLECULAR EPIDEMIOLOGY, CORECEPTOR USAGE, TRANSMISSION, INFECTION, SEQUENCES, COHORT, Acquired Immunodeficiency Syndrome, Adult, Biological Evolution, Coinfection, Drug Resistance, Viral, Female, Genetic Variation, HIV Infections, Humans, Male, Retrospective Studies, Sexual Behavior, Viral Load, Young Adult, env Gene Products, Human Immunodeficiency Virus, pol Gene Products, Human Immunodeficiency Virus, 1103 Clinical Sciences, 1117 Public Health and Health Services, 3202 Clinical sciences, 4202 Epidemiology

Abstract:

Clinicians reported an increasing trend of rapid progression (RP) (AIDS within 3 years of infection) in Cuba.