Gastrointestinal behavior of nano- and microsized fenofibrate: In vivo evaluation in man and in vitro simulation by assessment of the permeation potential

Hens, Bart; Brouwers, Joachim; Corsetti, Maura; Augustijns, Patrick

doi:10.1016/j.ejps.2015.05.023

Gastrointestinal behavior of nano- and microsized fenofibrate: In vivo evaluation in man and in vitro simulation by assessment of the permeation potential

Author:

Hens, Bart

Brouwers, Joachim ; Corsetti, Maura ; Augustijns, Patrick

Keywords:

Science & Technology, Life Sciences & Biomedicine, Pharmacology & Pharmacy, Dissolution, Permeation, Solubility-permeability interplay, Fenofibrate, Nanoparticles, Microparticles, Dialysis, Clinical study, HUMAN INTESTINAL FLUIDS, PHARMACOKINETIC EVALUATION, DRUG SOLUBILITY, ORAL DELIVERY, DISSOLUTION, ABSORPTION, BIOAVAILABILITY, PERMEABILITY, FORMULATION, CLASSIFICATION, Solubility–permeability interplay, Gastrointestinal Tract, Humans, Hypolipidemic Agents, In Vitro Techniques, Microspheres, Solubility, 1115 Pharmacology and Pharmaceutical Sciences, 3214 Pharmacology and pharmaceutical sciences

Abstract:

The purpose of this study was (i) to evaluate the gastrointestinal behavior of micro- and nanosized fenofibrate in humans and (ii) to develop a simple yet qualitatively predictive in vitro setup that simulates the observed absorption-determining factors.