Title: Belgian multicenter experience with intestinal transplantation
Authors: Ceulemans, Laurens ×
Monbaliu, Diethard
De Roover, Arnaud
Detry, Olivier
Troisi, Roberto
Rogiers, Xavier
Raymond, Reding
Lerut, Jan
Ysebaert, Dirk
Chapelle, Thierry
Pirenne, Jacques #
Issue Date: Dec-2015
Publisher: Springer International
Series Title: Transplant International vol:28 issue:12 pages:1362-70
Article number: 10.1111/tri.12615
Abstract: Intestinal transplantation (ITx) has evolved from an experimental procedure towards a clinical reality but remains a challenging procedure. The aim of this survey was to analyze the multicenter Belgian ITx-experience. From 1999-2014, 24 ITx in 23 patients were performed in Belgium, divided over 5 centers. Median recipient age was 38 years (8 months-57 years); male/female ratio was 13/10; 6 were children and 17 adults. Intestinal failure was related to intestinal ischemia(n=5), volvulus(n=5), splanchnic thrombosis(n=4), Crohn(n=2), pseudo-obstruction(n=2), microvillus inclusion(n=2), Churg-Strauss(n=1), necrotizing enterocolitis(n=1), intestinal atresia(n=1) and chronic rejection(n=1). Graft-type was isolated ITx(n=9), combined liver-ITx(n=11) and multivisceralTx(n=4). One was a living donor-related transplantation and five patients received simultaneously a kidney graft. Early acute rejection occurred in 8; late acute rejection in 4 and chronic rejection in 2. Two patients developed a post-transplant lymphoproliferative disease. Nine patients have died. Among 14 survivors at last follow-up, 11 have been transplanted for more than 1 year. None of the latter has developed renal failure and all were nutritionally independent with a Karnofsky score >90%. 1-/5-year patient and graft survivals were 71.1%/62.8% and 58.7%/53.1%, respectively. Based on this experience, ITx has come of age in Belgium as a life-saving and potentially quality of life restoring therapy. This article is protected by copyright. All rights reserved.
ISSN: 0934-0874
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Abdominal Transplantation
× corresponding author
# (joint) last author

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