Title: NUP98/11p15 translocations affect CD34+ cells in myeloid and T lymphoid leukemias
Authors: Crescenzi, Barbara ×
Nofrini, Valeria
Barba, Gianluca
Matteucci, Caterina
Di Giacomo, Danika
Gorello, Paolo
Beverloo, Berna
Vitale, Antonella
Wlodarska, Iwona
Vandenberghe, Peter
La Starza, Roberta
Mecucci, Cristina #
Issue Date: Jul-2015
Publisher: Pergamon Press
Series Title: Leukemia Research vol:39 issue:7 pages:769-72
Article number: S0145-2126(15)00125-3
Abstract: We assessed lineage involvement by NUP98 translocations in myelodysplastic syndromes (MDS), acute myeloid leukaemia (AML), and T-cell acute lymphoblastic leukaemia (T-ALL). Single cell analysis by FICTION (Fluorescence Immunophenotype and Interphase Cytogenetics as a Tool for Investigation of Neoplasms) showed that, despite diverse partners, i.e. NSD1, DDX10, RAP1GDS1, and LNP1, NUP98 translocations always affected a CD34+/CD133+ hematopoietic precursor. Interestingly the abnormal clone included myelomonocytes, erythroid cells, B- and T- lymphocytes in MDS/AML and only CD7+/CD3+ cells in T-ALL. The NUP98-RAP1GDS1 affected different hematopoietic lineages in AML and T-ALL. Additional specific genomic events, were identified, namely FLT3 and CEBPA mutations in MDS/AML, and NOTCH1 mutations and MYB duplication in T-ALL.
ISSN: 0145-2126
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Laboratory for Genetics of Malignant Disorders
× corresponding author
# (joint) last author

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