Common germline polymorphisms associated with breast cancer specific survival

Pirie, Ailith; Guo, Qi; Kraft, Peter; Canisius, Sander; Eccles, Diana M; Rahman, Nazneen; Nevanlinna, Heli; Chen, Constance; Khan, Sofia; Tyrer, Jonathan; Bolla, Manjeet K; Jakubowska, Anna; Lubinski, Jan; Gronwald, Jacek; Durda, Katarzyna; Hamann, Ute; Kabisch, Maria; Ulmer, Hans Ulrich; Rüdiger, Thomas; Margolin, Sara; Kristensen, Vessela; Wang, Q; Nord, Siljie; NBCS Investigators,; Evans, D Gareth; Abraham, Jan; Earl, Helena; Poole, Christopher J; Hiller, Louise; Dunn, Janet A; Bowden, Sarah; Yang, Rose; Dennis, Joe; Campa, Daniele; Diver, W Ryan; Gapstur, Susan M; Gaudet, Mia M; Hankinson, Susan; Hoover, Robert N; Hüsing, Anika; Kaaks, Rudolf; Machiela, Mitchell J; Willett, Walter; Michailidou, Kyriaki; Barrdahl, Myrto; Canzian, Federico; Chin, Suet-Feung; Caldas, Carlos; Hunter, David J; Lindstrom, Sara; Garcia-Closas, Montserrat; Couch, Fergus J; Chenevix-Trench, Georgia; Mannermaa, Arto; Lush, Michael; Andrulis, Irene L; Hall, Per; Chang-Claude, Jenny; Easton, Douglas F; Bojesen, Stig E; Cox, Angela; Fasching, Peter A; Pharoah, Paul Dp; Schmidt, Marjanka K; Dunning, Alison M; Shah, Mitul; Czene, Kamila; Darabi, Hatef; Eriksson, Mikael; Lambrechts, Diether; Weltens, Caroline; Leunen, Karin; Van Ongeval, Chantal; Nordestgaard, Børge G; Nielsen, Sune F; Flyger, Henrik; Rudolph, Anja; Seibold, Petra; Flesch-Janys, Dieter; Blomqvist, Carl; Aittomäki, Kristiina; Fagerholm, Rainer; Muranen, Taru A; Olsen, Janet E; Hallberg, Emily; Vachon, Celine; Knight, Julia A; Glendon, Gord; Mulligan, Anna Marie; Broeks, Annegien; Cornelissen, Sten; Haiman, Christopher A; Henderson, Brian E; Schumacher, Frederick; Le Marchand, Loic; Hopper, John L; Tsimiklis, Helen; Apicella, Carmel; Southey, Melissa C; Cross, Simon S; Reed, Malcolm Wr; Giles, Graham G; Milne, Roger L; McLean, Catriona; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Hooning, Maartje J; Hollestelle, Antoinette; Martens, John Wm; van den Ouweland, Ans Mw; Marme, Federick; Schneeweiss, Andreas; Yang, Rongxi; Burwinkel, Barbara; Figueroa, Jonine; Chanock, Stephen J; Lissowska, Jolanta; Sawyer, Elinor J; Tomlinson, Ian; Kerin, Michael J; Miller, Nicola; Brenner, Hermann; Butterbach, Katja; Holleczek, Bernd; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M; Li, Jingmei; Brand, Judith S; Humphreys, Keith; Devilee, Peter; Tollenaar, Robert Aem; Seynaeve, Caroline; Radice, Paolo; Peterlongo, Paolo; Manoukian, Siranoush; Ficarazzi, Filomena; Beckmann, Matthias W; Hein, Alexander; Ekici, Arif B; Balleine, Rosemary; Phillips, Kelly-Anne; kConFab Investigators,; Benitez, Javier; Zamora, M Pilar; Perez, Jose Ignacio Arias; Menéndez, Primitiva

doi:10.1186/s13058-015-0570-7

Common germline polymorphisms associated with breast cancer specific survival

Author:

Pirie, Ailith

Guo, Qi ; Kraft, Peter ; Canisius, Sander ; Eccles, Diana M ; Rahman, Nazneen ; Nevanlinna, Heli ; Chen, Constance ; Khan, Sofia ; Tyrer, Jonathan ; Bolla, Manjeet K ; Jakubowska, Anna ; Lubinski, Jan ; Gronwald, Jacek ; Durda, Katarzyna ; Hamann, Ute ; Kabisch, Maria ; Ulmer, Hans Ulrich ; Rüdiger, Thomas ; Margolin, Sara ; Kristensen, Vessela ; Wang, Q ; Nord, Siljie ; NBCS Investigators, ; Evans, D Gareth ; Abraham, Jan ; Earl, Helena ; Poole, Christopher J ; Hiller, Louise ; Dunn, Janet A ; Bowden, Sarah ; Yang, Rose ; Dennis, Joe ; Campa, Daniele ; Diver, W Ryan ; Gapstur, Susan M ; Gaudet, Mia M ; Hankinson, Susan ; Hoover, Robert N ; Hüsing, Anika ; Kaaks, Rudolf ; Machiela, Mitchell J ; Willett, Walter ; Michailidou, Kyriaki ; Barrdahl, Myrto ; Canzian, Federico ; Chin, Suet-Feung ; Caldas, Carlos ; Hunter, David J ; Lindstrom, Sara ; Garcia-Closas, Montserrat ; Couch, Fergus J ; Chenevix-Trench, Georgia ; Mannermaa, Arto ; Lush, Michael ; Andrulis, Irene L ; Hall, Per ; Chang-Claude, Jenny ; Easton, Douglas F ; Bojesen, Stig E ; Cox, Angela ; Fasching, Peter A ; Pharoah, Paul Dp ; Schmidt, Marjanka K ; Dunning, Alison M ; Shah, Mitul ; Czene, Kamila ; Darabi, Hatef ; Eriksson, Mikael ; Lambrechts, Diether ; Weltens, Caroline ; Leunen, Karin ; Van Ongeval, Chantal ; Nordestgaard, Børge G ; Nielsen, Sune F ; Flyger, Henrik ; Rudolph, Anja ; Seibold, Petra ; Flesch-Janys, Dieter ; Blomqvist, Carl ; Aittomäki, Kristiina ; Fagerholm, Rainer ; Muranen, Taru A ; Olsen, Janet E ; Hallberg, Emily ; Vachon, Celine ; Knight, Julia A ; Glendon, Gord ; Mulligan, Anna Marie ; Broeks, Annegien ; Cornelissen, Sten ; Haiman, Christopher A ; Henderson, Brian E ; Schumacher, Frederick ; Le Marchand, Loic ; Hopper, John L ; Tsimiklis, Helen ; Apicella, Carmel ; Southey, Melissa C ; Cross, Simon S ; Reed, Malcolm Wr ; Giles, Graham G ; Milne, Roger L ; McLean, Catriona ; Winqvist, Robert ; Pylkäs, Katri ; Jukkola-Vuorinen, Arja ; Grip, Mervi ; Hooning, Maartje J ; Hollestelle, Antoinette ; Martens, John Wm ; van den Ouweland, Ans Mw ; Marme, Federick ; Schneeweiss, Andreas ; Yang, Rongxi ; Burwinkel, Barbara ; Figueroa, Jonine ; Chanock, Stephen J ; Lissowska, Jolanta ; Sawyer, Elinor J ; Tomlinson, Ian ; Kerin, Michael J ; Miller, Nicola ; Brenner, Hermann ; Butterbach, Katja ; Holleczek, Bernd ; Kataja, Vesa ; Kosma, Veli-Matti ; Hartikainen, Jaana M ; Li, Jingmei ; Brand, Judith S ; Humphreys, Keith ; Devilee, Peter ; Tollenaar, Robert Aem ; Seynaeve, Caroline ; Radice, Paolo ; Peterlongo, Paolo ; Manoukian, Siranoush ; Ficarazzi, Filomena ; Beckmann, Matthias W ; Hein, Alexander ; Ekici, Arif B ; Balleine, Rosemary ; Phillips, Kelly-Anne ; kConFab Investigators, ; Benitez, Javier ; Zamora, M Pilar ; Perez, Jose Ignacio Arias ; Menéndez, Primitiva

Keywords:

Science & Technology, Life Sciences & Biomedicine, Oncology, SINGLE-NUCLEOTIDE POLYMORPHISMS, GENOME-WIDE ASSOCIATION, THAN-T POLYMORPHISM, GENETIC POLYMORPHISMS, ADJUVANT THERAPY, RISK, PROGNOSIS, VARIANTS, GENOTYPE, OUTCOMES, Breast Neoplasms, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genome-Wide Association Study, Germ Cells, Humans, Polymorphism, Single Nucleotide, Prognosis, kConFab Investigators, NBCS Investigators, 1112 Oncology and Carcinogenesis, Oncology & Carcinogenesis, 3211 Oncology and carcinogenesis

Abstract:

Previous studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was to evaluate the association of previously reported SNPs with breast cancer specific survival using data from a pooled analysis of eight breast cancer survival genome-wide association studies (GWAS) from the Breast Cancer Association Consortium.