Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Endocrinology & Metabolism, Pediatrics, Placenta, Fetal growth, Mitochondrial DNA, Superoxide dismutase activity, Small for gestational age, FOR-GESTATIONAL-AGE, OXIDATIVE STRESS, INSULIN-RESISTANCE, ANTIOXIDANT STATUS, ATHEROSCLEROSIS, RESTRICTION, DYSFUNCTION, DEPLETION, NEWBORNS, DAMAGE, Adult, DNA, Mitochondrial, Female, Fetal Growth Retardation, Humans, Mitochondria, Pregnancy, Superoxide Dismutase, 1103 Clinical Sciences, 1114 Paediatrics and Reproductive Medicine, 3202 Clinical sciences, 3213 Paediatrics, 3215 Reproductive medicine

Abstract:

Prenatal growth restraint is associated with increased oxidative stress--as judged by mitochondrial dysfunction--in pregnancies complicated by preeclampsia or diabetes, but it is uncertain whether this is also the case in uncomplicated pregnancies. We assessed the link between fetal growth restraint and placental mitochondrial dysfunction, as reflected by changes in mitochondrial DNA (mtDNA) content and superoxide dismutase (SOD) activity.