Title: Menstruation pulls the trigger for inflammation and pain in endometriosis
Authors: Laux-Biehlmann, Alexis ×
D'Hooghe, Thomas
Zollner, Thomas M #
Issue Date: May-2015
Publisher: Elsevier Publications
Series Title: Trends in Pharmacological Sciences vol:36 issue:5 pages:270-276
Article number: S0165-6147(15)00044-9
Abstract: Endometriosis is a chronic, hormone-dependent, inflammatory disease, characterized by the presence and growth of endometrial tissue outside the uterine cavity. It affects 5-10% of the female population of reproductive age and is frequently associated with moderate to severe pain, subfertility, and a marked reduction in health-related quality of life. Here, we propose a new pathophysiological concept of endometriosis, summarizing recent findings in one unifying picture. We propose menstruating tissue as the trigger for inflammatory pain in endometriosis through the activation of innate immune cells and peripheral nerve endings. We speculate how innovative treatment modalities beyond hormonal treatment will improve patients' lives.
ISSN: 0165-6147
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Organ Systems (+)
× corresponding author
# (joint) last author

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