Geographical patterns of the standing and active human gut microbiome in health and IBD
Rehman, Ateequr Rausch, Philipp Wang, Jun Skieceviciene, Jurgita Kiudelis, Gediminas Bhagalia, Ketan Amarapurkar, Deepak Kupcinskas, Limas Schreiber, Stefan Rosenstiel, Philip Baines, John F Ott, Stephan # ×
BMJ Publishing Group
Gut vol:65 issue:2 pages:238-48
A global increase of IBD has been reported, especially in countries that previously had low incidence rates. Also, the knowledge of the human gut microbiome is steadily increasing, however, limited information regarding its variation on a global scale is available. In the light of the microbial involvement in IBDs, we aimed to (1) identify shared and distinct IBD-associated mucosal microbiota patterns from different geographical regions including Europe (Germany, Lithuania) and South Asia (India) and (2) determine whether profiling based on 16S rRNA transcripts provides additional resolution, both of which may hold important clinical relevance.