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Title: Analysis of intestinal microbiota in hybrid house mice reveals evolutionary divergence in a vertebrate hologenome
Authors: Wang, Jun
Kalyan, Shirin
Steck, Natalie
Turner, Leslie M
Harr, Bettina
Künzel, Sven
Vallier, Marie
Häsler, Robert
Franke, Andre
Oberg, Hans-Heinrich
Ibrahim, Saleh M
Grassl, Guntram A
Kabelitz, Dieter
Baines, John F # ×
Issue Date: 2015
Series Title: Nature Communications vol:6 pages:6440
Article number: 10.1038/ncomms7440
Abstract: Recent evidence suggests that natural selection operating on hosts to maintain their microbiome contributes to the emergence of new species, that is, the 'hologenomic basis of speciation'. Here we analyse the gut microbiota of two house mice subspecies, Mus musculus musculus and M. m. domesticus, across their Central European hybrid zone, in addition to hybrids generated in the lab. Hybrid mice display widespread transgressive phenotypes (that is, exceed or fall short of parental values) in a variety of measures of bacterial community structure, which reveals the importance of stabilizing selection operating on the intestinal microbiome within species. Further genetic and immunological analyses reveal genetic incompatibilities, aberrant immune gene expression and increased intestinal pathology associated with altered community structure among hybrids. These results provide unique insight into the consequences of evolutionary divergence in a vertebrate 'hologenome', which may be an unrecognized contributing factor to reproductive isolation in this taxonomic group.
URI: 
ISSN: 2041-1723
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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