Title: 3-Cyclopentyl-1-adamantanamines and adamantanemethanamines. Antiviral activity evaluation and convulsions studies
Authors: Fytas, G ×
Marakos, P
Kolocouris, N
Foscolos, G B
Pouli, N
Vamvakides, A
Ikeda, S
De Clercq, Erik #
Issue Date: Oct-1994
Publisher: Elsevier France, Editions Scientifiques et Medicales
Series Title: Il Farmaco vol:49 issue:10 pages:641-7
Abstract: The synthesis of 3-cyclopentyl-1-adamantanamines and adamantanemethanamines and some of their thioureas is described. The antiviral activity examination of these compounds indicated that some of them inhibited Respiratory Syncytial Virus (RSV) infection at concentrations that were slightly (up to 5-fold) lower than the cytotoxic concentration. Behavioral and convulsions studies of the above mentioned amines, in mice, did not show any dopaminomimetic activity and argue in favor of the existence of a glutamatergic component in the action of these derivatives.
ISSN: 0014-827X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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