Title: Mathematical difficulties and white matter abnormalities in subacute pediatric mild traumatic brain injury
Authors: Van Beek, Leen
Ghesquière, Pol
Lagae, Lieven
De Smedt, Bert # ×
Issue Date: 2015
Publisher: M.A. Liebert
Series Title: Journal of Neurotrauma vol:32 issue:20 pages:1567-1578
Abstract: Mathematical difficulties have been documented following pediatric mild traumatic brain injury (mTBI), yet a precise characterization of these impairments and their neural correlates is currently unavailable. We aimed to characterize these impairments by comparing behavioral and neuroimaging (i.e. diffusion tensor imaging or DTI) outcomes from children with subacute mTBI to typically developing controls. Twenty subacute pediatric mTBI patients and 20 well-matched controls underwent cognitive assessment and DTI examination. DTI tractography was used to detect white matter abnormalities in the corpus callosum (CC) and superior and inferior longitudinal fasciculi; these tracts are involved in mathematical performance and they are often damaged after mTBI. Behavioral results revealed that children with mTBI performed significantly more poorly on rapid apprehension of small numbers of objects (or ‘subitizing’), processing of non-symbolic numerosities and procedural problem solving. These group differences were explained by differences in visuospatial working memory, which suggests that the observed mathematical difficulties may be a consequence of impairments in visuospatial abilities. DTI analysis revealed subtle group differences in the CC genu and splenium, i.e. higher fractional anisotropy and lower mean and radial diffusivity in children with mTBI, but the observed white matter abnormalities of the CC were not significantly associated with the observed mathematical difficulties in the mTBI patients.
ISSN: 0897-7151
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Parenting and Special Education
Organ Systems (+)
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
Leen_J of Neurotrauma_revision_15April2015.pdf Accepted 676KbAdobe PDFView/Open Request a copy
VanBeek_Journal of Neurotrauma_OA.pdf"OA article" Accepted 742KbAdobe PDFView/Open
Leen_J of Neurotrauma_epub ahead of printing.pdfpreprint Accepted 187KbAdobe PDFView/Open Request a copy
Leen_J of Neurotrauma_published.pdfPublished article Published 191KbAdobe PDFView/Open Request a copy

These files are only available to some KU Leuven Association staff members


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science