Title: Supported Gold Nanoparticles as an Efficient and Reusable Heterogeneous Catalyst for Cycloisomerization Reactions
Authors: Schröder, Felix
Ojeda, Manuel
Erdmann, Nico
Jacobs, Jeroen
Luque, Rafael
Noël, Timothy
Van Meervelt, Luc
Van der Eycken, Johan
Van der Eycken, Erik # ×
Issue Date: 7-Apr-2015
Publisher: Royal Society of Chemistry
Series Title: Green Chemistry vol:17 issue:6 pages:3314-3318
Article number: 10.1039/C5GC00430F
Abstract: We report the utilization of a novel catalyst for cycloisomerizations. The novel catalyst system contains
gold nanoparticles supported on Al-SBA15, which was prepared by the ball-milling process. We developed
a greener methodology for synthesizing spiroindolines under heterogeneous conditions, using this novel
class of supported gold nanoparticles in combination with microwave irradiation. The catalyst is highly
reusable and selective. Cycloisomerization reaction yields ranged from good to excellent leading to the
formation of two novel classes of six- and seven-membered heterocycles, which have been unprece-
dented so far. The selectivity of the catalyst towards the desired products is high and the reaction can be
performed in ethanol as the solvent. A one-pot cascade reaction could be established commencing with
the Ugi-reaction to ensure diversity.
ISSN: 1463-9262
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
Biochemistry, Molecular and Structural Biology Section
× corresponding author
# (joint) last author

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