Title: New neplanocin analogues. Synthesis and antiviral activity of 6'-modified neplanocin A derivatives
Authors: Shuto, S ×
Obara, T
De Clercq, Erik #
Issue Date: 1991
Publisher: Information Retrieval Ltd.
Series Title: Nucleic Acids Symposium Series issue:25 pages:7-8
Abstract: Novel neplanocin A analogues modified at the 6'-position, i.e. 6'-deoxy derivatives (2, 3, 5, 6, 14), 6'-O-methylneplanocin A (10) and 6'-C-methylneplanocin A (16a and 16b) were synthesized and evaluated for their antiviral activity in a wide variety of virus systems. Compound 16a (TJ-13025) surpassed neplanocin A both in antiviral potency and selectivity.
ISSN: 0261-3166
Publication status: published
KU Leuven publication type: IC
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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