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Title: The genetics of loneliness: Linking evolutionary theory to genome-wide genetics, epigenetics, and social science
Authors: Goossens, Luc ×
Van Roekel, Eeske
Verhagen, Maaike
Cacioppo, John T.
Cacioppo, Stephanie
Maes, Marlies
Boomsma, Dorret I. #
Issue Date: 2015
Series Title: Perspectives on Psychological Science vol:10 issue:2 pages:213-226
Abstract: As a complex trait, loneliness is likely to be influenced by the interplay of numerous genetic and environmental factors. Studies in behavioral genetics indicate that loneliness has a sizable degree of heritability. Candidate-gene and geneexpression studies have pointed to several genes related to neurotransmitters and the immune system. The notion
that these genes are related to loneliness is compatible with the basic tenets of the evolutionary theory of loneliness. Research on gene-environment interactions indicates that social-environmental factors (e.g., low social support) may have a more pronounced effect and lead to higher levels of loneliness if individuals carry the sensitive variant of these candidate genes. Currently, there is no extant research on loneliness based on genome-wide association studies, geneenvironment-
interaction studies, or studies in epigenetics. Such studies would allow researchers to identify networks
of genes that contribute to loneliness. The contribution of genetics to loneliness research will become stronger when genome-wide genetics and epigenetics are integrated and used along with well-established methods in psychology to analyze the complex process of gene-environment interplay.
ISSN: 1745-6916
Publication status: published
KU Leuven publication type: IT
Appears in Collections:School Psychology and Child and Adolescent Development
× corresponding author
# (joint) last author

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