Lung transplantation is an established treatment for patients with end-stage lung disease. It has been observed that despite near-normal lung function, exercise intolerance and reductions in quality of life often persist up to years after transplantation. Several modifiable pre- and post-transplant factors are known to contribute to these persisting impairments. Physiological changes associated with severe and chronic lung disease, limb muscle dysfunction, inactivity/deconditioning, and nutritional depletion can affect exercise capacity and physical functioning in candidates for lung transplantation. Following transplant, extended hospital and intensive care stay, prolonged sedentary time and persisting inactivity, immunosuppressant medications and episodes of organ rejection may all impact the lung recipients’ recovery. Available evidence will be reviewed and content will be proposed (both evidence and experience based) for rehabilitation interventions prior to transplantation, during hospitalization following transplantation, and in both the immediate (up to 12 months after hospital discharge), and long-term (longer than 12 months after hospital discharge) post-transplant phase. Outpatient rehabilitation programs including supervised exercise training have been shown to be effective in improving limb muscle dysfunction, exercise capacity, and quality of life both pre- and post-transplant, if offered appropriately. Unmet research needs included the absence of sufficiently powered RCTs measuring effects of rehabilitation interventions on crucial long-term outcomes such as sustained improvements in QOL, participation in daily activity, survival, incidence of morbidities and cost-effectiveness. Remotely monitored (tele-health) home based exercise, or pedometer based walking interventions might be interesting alternatives to supervised outpatient rehabilitation interventions in the long-term post-transplant phase that warrant further investigation.