ITEM METADATA RECORD
Title: Growth in virologically suppressed HIV positive children on antiretroviral therapy: individual and population-level references
Authors: Keiser, Olivia ×
Blaser, Nello
Davies, Mary-Ann
Wessa, Patrick
Eley, Brian
Moultrie, Harry
Rabie, Helena
Technau, Karl
Ndirangu, James
Garone, Daniela
Giddy, Janet
Grimwood, Ashraf
Gsponer, Thomas
Egger, Matthias #
Issue Date: 2015
Publisher: Williams & Wilkins
Series Title: The Pediatric Infectious Disease Journal vol:34 issue:10 pages:e254-e259
Abstract: Background
Combination antiretroviral therapy (ART) suppresses viral replication in HIV-infected
children. The growth of virologically suppressed children on ART has not been well
documented. We aimed to develop dynamic reference curves for weight-for-age z
scores (WAZ) and height-for-age z scores (HAZ).

Methods
Children aged <11 years at ART initiation with continuously undetectable viral loads
(<400 copies/ml) treated at seven South African ART programs with routine viral load
monitoring were included. We used multilevel models to define trajectories of WAZ and
HAZ up to 3 years and developed a web application to monitor trajectories in individual
children.

Results
A total of 4,876 children were followed for 7,407 person-years. Analyses were stratified
by baseline z-scores and age, which were the most important predictors of growth
response. The youngest children showed the most pronounced increase in weight and
height initially but catch-up growth stagnated after 1-2 years. Three years after starting
ART, WAZ ranged from -2.2 (95% Prediction interval -5.6 to 0.8) in children with
baseline age >5 years and z-score <-3 to 0.0 (-2.7 to 2.4) in children with baseline age
<2 years and WAZ >-1. For HAZ the corresponding range was -2.3 (-4.9 to 0.3) in
children with baseline age>5 years and z-score <-3 to 0.3 (-3.1 to 3.4) in children with
baseline age 2-5 years and HAZ >-1.

Conclusions
We have developed an online tool to calculate reference trajectories in fully
suppressed children. The web application could help to define 'optimal' growth
response and identify children with treatment failure.
ISSN: 0891-3668
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Marketing Management, Campus Carolus Antwerp
Faculty of Economics and Business (FEB) - miscellaneous
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
00006454-201510000-00015.pdf Published 710KbAdobe PDFView/Open Request a copy

These files are only available to some KU Leuven Association staff members

 




All items in Lirias are protected by copyright, with all rights reserved.

© Web of science