A multivariate electrophysiological endophenotype, from a unitary cohort, shows greater research utility than any single feature in the Western Australian family study of schizophrenia
Price, Gregory W × Michie, Patricia T Johnston, Julie Innes-Brown, Hamish Kent, Aaron Clissa, Peter Jablensky, Assen V #
Biological Psychiatry vol:60 issue:1 pages:1-10
Previous studies have found several electrophysiological endophenotypes that each co-varies individually with schizophrenia. This study extends these investigations to compare and contrast four electrophysiological endophenotype, mismatch negativity, P50, P300, and antisaccades, and analyze their covariance on the basis of a single cohort tested with all paradigms. We report a multivariate endophenotype that is maximally associated with diagnosis and evaluate this new endophenotype with respect to its application to genetic analysis.