Title: Urodynamic changes in mice with experimental autoimmune encephalomyelitis correlate with neurological impairment
Authors: Franken, Jan ×
Gevaert, Thomas
Uvin, Pieter
Wauterickx, K
Boeve, Anne-Cathérine
Rietjens, Roma
Boudes, M
Hendriks, J J A
Hellings, N
Voets, Thomas
De Ridder, Dirk #
Issue Date: Mar-2015
Publisher: Allen R. Liss
Series Title: Neurourology and Urodynamics vol:Ahead of print
Article number: 10.1002/nau.22742
Abstract: Neurogenic bladder dysfunction is a major issue in Multiple Sclerosis (MS). High intravesical pressure should be treated early. Available therapies are insufficient and there is need for drug development and investigation of pathogenesis. Experimental Autoimmune Encephalomyelitis (EAE) in rodents is a well validated model to study MS. Previous research has shown that these animals develop urinary symptoms. However, from clinical studies, we know that symptoms do not necessarily reflect changes in bladder pressure. This paper aims to provide a complete overview of urodynamic changes in a model for detrusor overactivity in MS.
ISSN: 0733-2467
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Ion Channel Research
Organ Systems (+)
× corresponding author
# (joint) last author

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