Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Rheumatology, systemic juvenile idiopathic arthritis, macrophage activation syndrome, haemophagocytic lymphohistiocytosis, IFN-gamma, IL-18, cytokine, plasma, peripheral blood mononuclear cells, MACROPHAGE ACTIVATION SYNDROME, IL-18 BINDING-PROTEIN, IFN-GAMMA, T-CELLS, PATHOGENESIS, EXPRESSION, PATHOPHYSIOLOGY, GUIDELINES, MANAGEMENT, DIAGNOSIS, IFN-γ, Adolescent, Arthritis, Juvenile, Biopsy, Case-Control Studies, Child, Child, Preschool, Cytokines, Diagnosis, Differential, Endothelial Cells, Female, Fibroblasts, Humans, Infant, Interferon-gamma, Interleukin-18, Interleukin-6, Leukocytes, Mononuclear, Lymph Nodes, Lymphohistiocytosis, Hemophagocytic, Macrophage Activation Syndrome, Male, Young Adult, 1103 Clinical Sciences, 1107 Immunology, 1117 Public Health and Health Services, Arthritis & Rheumatology, 3202 Clinical sciences, 3204 Immunology

Abstract:

To study the role of IFN-γ in the pathogenesis of systemic JIA (sJIA) and haemophagocytic lymphohistiocytosis (HLH) by searching for an IFN-γ profile, and to assess its relationship with other cytokines.