Metabolomic profile of amniotic fluid to evaluate lung maturity: the diaphragmatic hernia lamb model
Pelizzo, Gloria × Ballico, Maurizio Mimmi, Maria Chiara Peirò, José Louis Marotta, Mario Federico, Costanzo Andreatta, Erika Nakib, Ghassan Sampaolesi, Maurilio Zambaiti, Elisa Calcaterra, Valeria #
Multidisciplinary Respiratory Medicine vol:9 issue:1 pages:54
Tracheal occlusion (TO) stimulates lung growth in fetuses affected with congenital diaphragmatic hernia (CDH) although the processes involved in lung maturation still remain unknown. The objective of this study was to evaluate the metabolomic profile of amniotic fluid (AF) following TO in fetal lamb model in order to obtain an indirect view of mechanisms involved in pulmonary reversal hypoplasia and biochemical maturity in response to fetal TO.