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Title: A new approach to integrate toxicity grade and repeated treatment cycles in the analysis and reporting of phase I dose-finding trials
Authors: Doussau, A ×
Thiébaut, R
Geoerger, B
Schöffski, Patrick
Floquet, A
Le Deley, M C
Mathoulin-Pélissier, S
Rizzo, E
Fumoleau, P
Le Tourneau, C
Paoletti, X #
Issue Date: Feb-2015
Publisher: Kluwer Academic Publishers
Series Title: Annals of Oncology vol:26 issue:2 pages:422-8
Article number: 10.1093/annonc/mdu523
Abstract: Safety assessment beyond the dose-limiting toxicity evaluation period provides relevant information to define the recommended phase II dose (RP2D) of a new treatment. We retrospectively analyzed three phase I trials to illustrate two indicators: per-cycle probability of graded toxicity and cumulative probability of severe toxicity over the treatment period.
URI: 
ISSN: 0923-7534
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Oncology
× corresponding author
# (joint) last author

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