Title: Cell-fusion-mediated somatic-cell reprogramming: a mechanism for tissue regeneration
Authors: Lluis, Frederic
Cosma, Maria Pia # ×
Issue Date: Apr-2010
Publisher: Wiley Subscription Services, Inc.
Series Title: Journal of Cellular Physiology vol:223 issue:1 pages:6-13
Article number: 10.1002/jcp.22003
Abstract: Spontaneous cell fusion between two cells of different lineages will originate new hybrid cells that have different features from the original parent cells. It has been shown that injury to a tissue can enhance spontaneous cell-cell fusion events. If one of the parent cells of a cell-cell fusion is highly plastic, such as a stem cell, and the other is a somatic cell, their fusion can be followed by reprogramming events that can generate new hybrid pluripotent cells. These, in turn, have the potential to differentiate and regenerate the damaged tissue. However, if this process is deregulated, this would provide a mechanism for cancer development.
ISSN: 0021-9541
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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