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Title: Impact of the revised International Prognostic Scoring System, cytogenetics and monosomal karyotype on outcome after allogeneic stem cell transplantation for myelodysplastic syndromes and secondary acute myeloid leukemia evolving from myelodysplastic syndromes: a retrospective multicenter study of the European Society of Blood and Marrow Transplantation
Authors: Koenecke, Christian ×
Göhring, Gudrun
de Wreede, Liesbeth C
van Biezen, Anja
Scheid, Christof
Volin, Liisa
Maertens, Johan
Finke, Jürgen
Schaap, Nicolaas
Robin, Marie
Passweg, Jakob
Cornelissen, Jan
Beelen, Dietrich
Heuser, Michael
de Witte, Theo
Kröger, Nicolaus
MDS subcommittee of the Chronic Malignancies Working Party of the EBMT #
Issue Date: Mar-2015
Publisher: Il Pensiero Scientifico
Series Title: Haematologica vol:100 issue:3 pages:400-8
Article number: 10.3324/haematol.2014.116715
Abstract: The aim of this study was to determine the impact of the revised 5-group International Prognostic Scoring System cytogenetic classification on outcome after allogeneic stem cell transplantation in patients with myelodysplastic syndromes or secondary acute myeloid leukemia who were reported to the European Society for Blood and Marrow Transplantation database. A total of 903 patients had sufficient cytogenetic information available at stem cell transplantation to be classified according to the 5-group classification. Poor and very poor risk according to this classification was an independent predictor of shorter relapse-free survival (hazard ratio 1.40 and 2.14), overall survival (hazard ratio 1.38 and 2.14), and significantly higher cumulative incidence of relapse (hazard ratio 1.64 and 2.76), compared to patients with very good, good or intermediate risk. When comparing the predictive performance of a series of Cox models both for relapse-free survival and for overall survival, a model with simplified 5-group cytogenetics (merging very good, good and intermediate cytogenetics) performed best. Furthermore, monosomal karyotype is an additional negative predictor for outcome within patients of the poor, but not the very poor risk group of the 5-group classification. The revised International Prognostic Scoring System cytogenetic classification allows patients with myelodysplastic syndromes to be separated into three groups with clearly different outcomes after stem cell transplantation. Poor and very poor risk cytogenetics were strong predictors of poor patient outcome. The new cytogenetic classification added value to prediction of patient outcome compared to prediction models using only traditional risk factors or the 3-group International Prognostic Scoring System cytogenetic classification.
URI: 
ISSN: 0390-6078
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Hematology (+)
Laboratory of Clinical Bacteriology and Mycology
× corresponding author
# (joint) last author

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