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Title: A roadmap for interpreting (13)C metabolite labeling patterns from cells
Authors: Buescher, Joerg M
Antoniewicz, Maciek R
Boros, Laszlo G
Burgess, Shawn C
Brunengraber, Henri
Clish, Clary B
DeBerardinis, Ralph J
Feron, Olivier
Frezza, Christian
Ghesquiere, Bart
Gottlieb, Eyal
Hiller, Karsten
Jones, Russell G
Kamphorst, Jurre J
Kibbey, Richard G
Kimmelman, Alec C
Locasale, Jason W
Lunt, Sophia Y
Maddocks, Oliver Dk
Malloy, Craig
Metallo, Christian M
Meuillet, Emmanuelle J
Munger, Joshua
Nöh, Katharina
Rabinowitz, Joshua D
Ralser, Markus
Sauer, Uwe
Stephanopoulos, Gregory
St-Pierre, Julie
Tennant, Daniel A
Wittmann, Christoph
Vander Heiden, Matthew G
Vazquez, Alexei
Vousden, Karen
Young, Jamey D
Zamboni, Nicola
Fendt, Sarah-Maria # ×
Issue Date: Aug-2015
Publisher: Current Biology
Series Title: Current Opinion in Biotechnology vol:34 pages:189-201
Article number: S0958-1669(15)00022-1
Abstract: Measuring intracellular metabolism has increasingly led to important insights in biomedical research. (13)C tracer analysis, although less information-rich than quantitative (13)C flux analysis that requires computational data integration, has been established as a time-efficient method to unravel relative pathway activities, qualitative changes in pathway contributions, and nutrient contributions. Here, we review selected key issues in interpreting (13)C metabolite labeling patterns, with the goal of drawing accurate conclusions from steady state and dynamic stable isotopic tracer experiments.
URI: 
ISSN: 0958-1669
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Studiegebied Gezondheidszorg VIVES-Zuid
Laboratory for Cellular Metabolism and Metabolic Regulation (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

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