Title: Intestinal microbiota and diet in IBS: causes, consequences, or epiphenomena?
Authors: Rajilić-Stojanović, Mirjana ×
Jonkers, Daisy M
Salonen, Anne
Hanevik, Kurt
Raes, Jeroen
Jalanka, Jonna
de Vos, Willem M
Manichanh, Chaysavanh
Golic, Natasa
Enck, Paul
Philippou, Elena
Iraqi, Fuad A
Clarke, Gerard
Spiller, Robin C
Penders, John #
Issue Date: Feb-2015
Publisher: Nature Publishing Group
Series Title: American Journal of Gastroenterology vol:110 issue:2 pages:278-287
Article number: 10.1038/ajg.2014.427
Abstract: Irritable bowel syndrome (IBS) is a heterogeneous functional disorder with a multifactorial etiology that involves the interplay of both host and environmental factors. Among environmental factors relevant for IBS etiology, the diet stands out given that the majority of IBS patients report their symptoms to be triggered by meals or specific foods. The diet provides substrates for microbial fermentation, and, as the composition of the intestinal microbiota is disturbed in IBS patients, the link between diet, microbiota composition, and microbial fermentation products might have an essential role in IBS etiology. In this review, we summarize current evidence regarding the impact of diet and the intestinal microbiota on IBS symptoms, as well as the reported interactions between diet and the microbiota composition. On the basis of the existing data, we suggest pathways (mechanisms) by which diet components, via the microbial fermentation, could trigger IBS symptoms. Finally, this review provides recommendations for future studies that would enable elucidation of the role of diet and microbiota and how these factors may be (inter)related in the pathophysiology of IBS.
ISSN: 0002-9270
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Microbiology & Immunology - miscellaneous
Laboratory of Molecular Bacteriology (Rega Institute)
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
Am J Gastroenterol-Rajilic Stojanovic_2015.pdfOA article Published 1163KbAdobe PDFView/Open


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science