Title: Structure of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus in Complex with a Protective Monoclonal Antibody
Authors: Cho, Ki Joon
Schepens, Bert
Seok, Jong Hyeon
Kim, Sella
Roose, Kenny
Lee, Ji-Hye
Gallardo, Rodrigo
Hamme, Evelien Van
Schymkowitz, Joost
Rousseau, Frederic
Fiers, Walter
Saelens, Xavier ×
Kim, Kyung Hyun #
Issue Date: Apr-2015
Publisher: American Society for Microbiology (ASM)
Series Title: Journal of Virology vol:89 issue:7 pages:3700-11
Article number: JVI.02576-14
Abstract: The extracellular domain of influenza A virus matrix protein 2 (M2, M2e) is conserved and is being evaluated as a quasi-universal influenza A vaccine candidate. We describe the crystal structure at 1.6 Å resolution of M2e in complex with the Fab fragment of an M2e-specific monoclonal antibody that protects against influenza A virus challenge. This antibody binds M2 expressed on the surface of cells infected with influenza A virus. Five out of six complementary determining regions interact with M2e, and three highly conserved M2e residues are critical for this interaction. In this complex, M2e adopts a compact U-shaped conformation stabilized in the centre by the highly conserved tryptophan residue in M2e. This is the first description of the three dimensional structure of M2e.
ISSN: 0022-538X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Switch Laboratory (VIB-KU Leuven Center for Brain & Disease Research)
× corresponding author
# (joint) last author

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