Title: WALTZ-DB: a benchmark database of amyloidogenic hexapeptides
Authors: Beerten, Jacinte
Van Durme, Joost
Gallardo, Rodrigo
Capriotti, Emidio
Serpell, Louise
Rousseau, Frederic #
Schymkowitz, Joost # ×
Issue Date: May-2015
Publisher: Oxford University Press
Series Title: Bioinformatics vol:31 issue:10 pages:1698-700
Article number: btv027
Abstract: Accurate prediction of amyloid-forming amino acid sequences remains an important challenge. We here present an online database that provides open access to the largest set of experimentally characterized amyloid forming hexapeptides. To this end, we expanded our previous set of 280 hexapeptides used to develop the Waltz algorithm with 89 peptides from literature review and by systematic experimental characterisation of the aggregation of 720 hexapeptides by transmission electron microscopy, dye binding and Fourier transform infrared spectroscopy. This brings the total number of experimentally characterized hexapeptides in the WALTZ-DB database to 1089, of which 244 are annotated as positive for amyloid formation. Availability and implementation: The WALTZ-DB database is freely available without any registration requirement at
ISSN: 1367-4803
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Switch Laboratory
× corresponding author
# (joint) last author

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