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Title: Drosha, Dicer-1 and Argonaute-1 in the desert locust: phylogenetic analyses, transcript profiling and regulation during phase transition and feeding
Authors: Wynant, Niels ×
Cordeiro dos Santos, Dulce
Subramanyam, S. H.
Verlinden, Heleen
Vanden Broeck, Jozef #
Issue Date: Apr-2015
Publisher: Pergamon Press
Series Title: Journal of Insect Physiology vol:75 pages:20-292
Abstract: In this article, we identify and characterise the miRNA machinery components Drosha, Dicer-1 and Argonaute-1 of the desert locust. By means of phylogenetic analyses, we reveal important insights in the evolutionary context of these components. Our data illustrate that insect Argonaute-1 proteins form a monophyletic group with ALG-1 and ALG-2 of Caenorhabditis elegans and with the four (non-Piwi) Argonaute proteins present in humans. On the other hand, humans apparently lack clear homologues of the insect Argonaute-2 proteins. In addition, we demonstrate that drosha, dicer-1 and argonaute-1 display wide transcript tissue-distribution in adult desert locusts, and that during locust phase transition and feeding of starved locusts the expression levels of the miRNA pathway are regulated at the transcript level.
ISSN: 0022-1910
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
× corresponding author
# (joint) last author

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