Title: SEC31A-ALK Fusion Gene in Lung Adenocarcinoma
Authors: Kim, Ryong Nam
Choi, Yoon-La ×
Lee, Mi-Sook
Lira, Maruja E
Mao, Mao
Mann, Derrick
Stahl, Joshua
Licon, Abel
Choi, So Jung
Van Vrancken, Michael
Han, Joungho
Wlodarska, Iwona
Kim, Jhingook #
Issue Date: Jan-2016
Series Title: Cancer Research and Treatment vol:48 issue:1 pages:398-402
Article number: 10.4143/crt.2014.254
Abstract: Anaplastic lymphoma kinase (ALK) fusion is a common mechanism underlying pathogenesis of non-small cell lung carcinoma (NSCLC) where these rearrangements represent important diagnostic and therapeutic targets. In this study, we found a new ALK fusion gene, SEC31A-ALK, in lung carcinoma from a 53-year-old Korean man. The conjoined region in the fusion transcript was generated by the fusion of SEC31A exon 21 and ALK exon 20 by genomic rearrangement, which contributed to generation of an intact, in-frame open reading frame. SEC31A-ALK encodes a predicted fusion protein of 1438 amino acids comprising the WD40 domain of SEC31A at the N-terminus and ALK kinase domain at the C-terminus. FISH studies suggested that SEC31A-ALK was generated by an unbalanced genomic rearrangement associated with loss of the 3'end of SEC31A. This is the first report of SEC31A-ALK fusion transcript in clinical NSCLC, which could be a novel diagnostic and therapeutic target for patients with NSCLC.
ISSN: 1598-2998
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Genetics of Malignant Disorders
× corresponding author
# (joint) last author

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