Title: Mixed alkyl aryl phosphonate esters as quenched fluorescent activity-based probes for serine proteases
Authors: Serim, Sevnur ×
Baer, Philipp
Verhelst, Steven #
Issue Date: Feb-2015
Publisher: Royal Society of Chemistry
Series Title: Organic & Biomolecular Chemistry vol:13 issue:8 pages:2293-9
Article number: 10.1039/c4ob02444c
Abstract: Activity-based probes (ABPs) are powerful tools for the analysis of active enzyme species in whole proteomes, cells or animals. Quenched fluorescent ABPs (qABPs) can be applied for real time imaging, allowing the visualization of dynamic enzyme activation by fluorescent microscopy. Unfortunately, qABPs are only available for a few enzymes. We here describe the design and synthesis of qABPs for serine proteases based on a phosphonate ester scaffold.
ISSN: 1477-0520
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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