Title: How informative is the mouse for human gut microbiota research?
Authors: Nguyen, Thi Loan Anh
Vieira-Silva, Sara
Liston, Adrian
Raes, Jeroen # ×
Issue Date: Jan-2015
Publisher: The Company of Biologists Ltd.
Series Title: Disease Models and Mechanisms vol:8 issue:1 pages:1-16
Article number: 10.1242/dmm.017400
Abstract: The microbiota of the human gut is gaining broad attention owing to its association with a wide range of diseases, ranging from metabolic disorders (e.g. obesity and type 2 diabetes) to autoimmune diseases (such as inflammatory bowel disease and type 1 diabetes), cancer and even neurodevelopmental disorders (e.g. autism). Having been increasingly used in biomedical research, mice have become the model of choice for most studies in this emerging field. Mouse models allow perturbations in gut microbiota to be studied in a controlled experimental setup, and thus help in assessing causality of the complex host-microbiota interactions and in developing mechanistic hypotheses. However, pitfalls should be considered when translating gut microbiome research results from mouse models to humans. In this Special Article, we discuss the intrinsic similarities and differences that exist between the two systems, and compare the human and murine core gut microbiota based on a meta-analysis of currently available datasets. Finally, we discuss the external factors that influence the capability of mouse models to recapitulate the gut microbiota shifts associated with human diseases, and investigate which alternative model systems exist for gut microbiota research.
ISSN: 1754-8403
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Genetics of Autoimmunity
Laboratory of Molecular Bacteriology (Rega Institute)
× corresponding author
# (joint) last author

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