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Title: Cell based advanced therapeutic medicinal products for bone repair: Keep it simple?
Authors: Leijten, Jeroen ×
Chai, Yoke Chin
Papantoniou, Ioannis
Geris, Liesbet
Schrooten, Jan
Luyten, Frank #
Issue Date: 1-Nov-2014
Publisher: Elsevier Science Publishers, B.V.
Series Title: Advanced Drug Delivery Reviews vol:84 pages:30-44
Article number: ADR-12690
Abstract: The development of cell based advanced therapeutic medicinal products (ATMPs) for bone repair has been expected to revolutionize the health care system for the clinical treatment of bone defects. Despite this great promise, the clinical outcomes of the few cell based ATMPs that have been translated into clinical treatments have been far from impressive. In part, the clinical outcomes have been hampered because of the simplicity of the first wave of products. In response the field has set-out and amassed a plethora of complexities to alleviate the simplicity induced limitations. Many of these potential second wave products have remained “stuck” in the development pipeline. This is due to a number of reasons including the lack of a regulatory framework that has been evolving in the last years and the shortage of enabling technologies for industrial manufacturing to deal with these novel complexities. In this review, we reflect on the current ATMPs and give special attention to novel approaches that are able to provide complexity to ATMPs in a straightforward manner. Moreover, we discuss the potential tools able to produce or predict ‘goldilocks’ ATMPs, which are neither too simple nor too complex.
ISSN: 0169-409X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Skeletal Biology and Engineering Research Center (+)
Departement Lerarenopleiding - De Ark - UC Limburg
Biomechanics Section
Surface and Interface Engineered Materials
× corresponding author
# (joint) last author

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