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Title: Renal denervation in treatment-resistant hypertension: a reappraisal
Authors: Persu, Alexandre ×
Jin, Yu
Fadl Elmula, Fadl Elmula M
Renkin, Jean
Høieggen, Aud
Kjeldsen, Sverre E
Staessen, Jan A #
Issue Date: Apr-2015
Publisher: Elsevier Science Ltd.
Series Title: Current Opinion in Pharmacology vol:21 pages:48-52
Article number: S1471-4892(14)00180-5
Abstract: The Symplicity HTN-1 and 2 studies proposed renal denervation (RDN) as an effective and safe approach to treat patients with resistant hypertension, and were followed by an unprecedented wave of enthusiasm. The announcement that Symplicity HTN-3 failed to meet its primary efficacy endpoint put an abrupt stop to these overoptimistic expectations. The use of a sound methodology was enough to see the typical 25-30mmHg systolic blood pressure decrease observed after RDN melt down to <3mmHg. RDN certainly deserves further investigation but is not ready for wide clinical application. For the time being, physicians should focus on improvement of drug adherence and skilful drug treatment adjustment, which allow reaching blood pressure target in the large majority of hypertensive patients.
URI: 
ISSN: 1471-4892
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Cardiovascular Sciences - miscellaneous
Hypertension and Cardiovascular Epidemiology
× corresponding author
# (joint) last author

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