Title: ST-246 is a key antiviral to inhibit the viral F13L phospholipase, one of the essential proteins for orthopoxvirus wrapping
Authors: Duraffour, Sophie ×
Lorenzo, María M
Zöller, Gudrun
Topalis, Dimitrios
Grosenbach, Doug
Hruby, Dennis E
Andrei, Graciela
Blasco, Rafael
Meyer, Hermann
Snoeck, Robert #
Issue Date: May-2015
Publisher: Oxford University Press
Series Title: The Journal of Antimicrobial Chemotherapy vol:70 pages:1367-1380
Article number: dku545
Abstract: ST-246 is one of the key antivirals being developed to fight orthopoxvirus (OPV) infections. Its exact mode of action is not completely understood, but it has been reported to interfere with the wrapping of infectious virions, for which F13L (peripheral membrane protein) and B5R (type I glycoprotein) are required. Here we monitored the appearance of ST-246 resistance to identify its molecular target.
ISSN: 0305-7453
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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