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Title: Early exposure to bio-contaminants and asthma up to 10 years of age: results of the HITEA study
Authors: Tischer, Christina ×
Casas, Lidia
Wouters, Inge M
Doekes, Gert
Garcia-Esteban, Raquel
Gehring, Ulrike
Hyvärinen, Anne
Oldenwening, Marieke
Kerkhof, Marjan
Sunyer, Jordi
Standl, Marie
Thiering, Elisabeth
Torrent, Maties
Heinrich, Joachim
HITEA study group #
Issue Date: Feb-2015
Publisher: Published jointly by the Society and Munksgaard
Series Title: European Respiratory Journal vol:45 issue:2 pages:328-337
Article number: 10.1183/09031936.00060214
Abstract: Inverse associations have been found between exposure to bio-contaminants and asthma and allergies. The aim of this study was to prospectively assess whether early exposure to bio-contaminants in dust is associated with asthma and allergy later in childhood among children from (sub)-urban areas. In subsets of three European birth cohorts (PIAMA: n=553; INMA: n=481; and LISAplus: n=395), endotoxin, (1,3,)-β-d-glucan and extracellular polysaccharide were measured in dust from living rooms shortly after birth. Current asthma at 6 years and 10 years of age and ever asthma up to 10 years of age were assessed by parental questionnaires. Specific IgE levels at 8 years (PIAMA) and 10 years (LISAplus) were available. Adjusted, cohort-specific logistic regression analyses were performed. Higher endotoxin concentrations were positively associated with current asthma at 6 years of age in PIAMA (adjusted OR 1.96, 95% CI 1.07-3.58), but were inversely related with ever asthma up to 10 years of age in INMA (adjusted OR 0.39, 95% CI 0.16-0.94). No associations with asthma were found for LISAplus. No associations were observed with atopic sensitisation in all cohorts. All associations with (1,3)-β-d-glucan and extracellular polysaccharide were statistically nonsignificant. The suggested immunological mechanisms of early exposure to bio-contaminants with regards to asthma and allergy might be different for children growing up in (sub)-urban environments.
URI: 
ISSN: 0903-1936
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Environment and Health - miscellaneous
× corresponding author
# (joint) last author

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